Nichola Conlon
NR vs NMN is Dated, Boosting NAD+ to New Levels – EP21: Nichola Conlon (Nuchido)
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In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.
She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.
Topics we discussed in this episode
- Recent personal experience with COVID-19
- Her molecular biology PhD focus
- Systems pharmacology
- Help from Aubrey de Gray
- Disillusioned with drug development
- Founding Nuchido
- What are Sirtuins? What is NAD?
- Importance of NAD. Why Boost NAD Levels?
- Inefficiency of First-Gen NAD Supplements: NR and NMN
- Three ingredients to boost NAD
- Pure NAD limitations
- Nicotinamide Riboside (NR)
- Nicotinamide Mononucleotide (NMN)
- 60% increase in NAD “only”
- Second-gen, demonstrated it can be done much better if you take a whole systems approach
- Importance of NAD salvage pathway
- PARP enzymes
- Inability to power sustained high-levels because of salvage pathway deterioration
- First-gen may not be great for epigenetics
- Increases expression of the enzymes in the salvage pathway that are known to decline with age
- Ingredients that reduce the expression of other processes that are actually wasting NAD
- Enzyme called CD38
- Inflammatory levels – CD38 just chews up NAD
- Multiple things that you can do to fix the cell before you even need to put precursors in.
- NAD decreases with age
- Do we Need NAD Supplements?
- Sirtuins and mitochondrial biogenesis
- Boosting your NAD levels, improves mitochondrial function.
- Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve
- Second-gen helps fixe your body’s natural ability to make and recycle its own NAD
- Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen
- ChromaDex vs Elyisum Health
- Terms B3, niacin, nicotinamide, nicotinic acid, NR
- Abram Hoffer and orthomolecular medicine
- Nicotinamide is not likely to be a sirtuin inhibitor,
- How to measure NAD levels
- Nuchido TIME+ ingredients
- Alpha lipoic acid (ALA) and effects on AMPK
- Conversion of NADH to NAD+
- Drift more towards having more NADH in your cell with age
- Pathway called NQO1, converts NADH back to NAD+
- ALA is a really powerful antioxidant, activates NRF2
- ALA vs ALA-R
- Sophora Japonica Extract Rutin, senolytic
- NAMP
- Aging is an inflicted cascade disorder
Show links
- Nuchido (Company Website)
- ChromaDex (Company Website)
- Elysium Health (Company Website)
- Elysium Health, Inc. Loses Appeal of Patent Challenge Decision (Press Release)
- Orthomolecular Medicine (Wikipedia Entry)
- Abram Hoffer (Wikipedia Entry)
- Niacin: The Real Story: Learn about the Wonderful Healing Properties of Niacin (Amazon, Book)
- Orthomolecular Medicine for Everyone (Amazon, Book)
- GlycanAge (Company Website)