Nichola Conlon

NR vs NMN is Dated, Boosting NAD+ to New Levels – EP21: Nichola Conlon (Nuchido)

In this twenty-first episode, Nichola Conlon provides a scientific background, introducing sirtuins and NAD. She then explains why popular NAD+ boosters, NR and NMN, are first-gen products.

Read the transcript

She details how Nuchido formulated the first second-gen product by taking a novel whole systems approach. Lots of NAD, anti-aging, and nutraceutical discussion along the way.

Topics we discussed in this episode
  • Recent personal experience with COVID-19
  • Her molecular biology PhD focus
  • Systems pharmacology
  • Help from Aubrey de Gray
  • Disillusioned with drug development
  • Founding Nuchido
  • What are Sirtuins? What is NAD?
  • Importance of NAD. Why Boost NAD Levels?
  • Inefficiency of First-Gen NAD Supplements: NR and NMN
  • Three ingredients to boost NAD
  • Pure NAD limitations
  • Nicotinamide Riboside (NR)
  • Nicotinamide Mononucleotide (NMN)
  • 60% increase in NAD “only”
  • Second-gen, demonstrated it can be done much better if you take a whole systems approach
  • Importance of NAD salvage pathway
  • PARP enzymes
  • Inability to power sustained high-levels because of salvage pathway deterioration
  • First-gen may not be great for epigenetics
  • Increases expression of the enzymes in the salvage pathway that are known to decline with age
  • Ingredients that reduce the expression of other processes that are actually wasting NAD
  • Enzyme called CD38
  • Inflammatory levels – CD38 just chews up NAD
  • Multiple things that you can do to fix the cell before you even need to put precursors in.
  • NAD decreases with age
  • Do we Need NAD Supplements?
  • Sirtuins and mitochondrial biogenesis
  • Boosting your NAD levels, improves mitochondrial function.
  • Multiple reasons that are causing the NAD to decline, boosting as with first-gen only the amount of raw material that your cell has is quite naïve
  • Second-gen helps fixe your body’s natural ability to make and recycle its own NAD
  • Nuchido TIME+ boosts NAD on average by 242%, four times more than the 60% widely cited for first-gen
  • ChromaDex vs Elyisum Health
  • Terms B3, niacin, nicotinamide, nicotinic acid, NR
  • Abram Hoffer and orthomolecular medicine
  • Nicotinamide is not likely to be a sirtuin inhibitor,
  • How to measure NAD levels
  • Nuchido TIME+ ingredients
  • Alpha lipoic acid (ALA) and effects on AMPK
  • Conversion of NADH to NAD+
  • Drift more towards having more NADH in your cell with age
  • Pathway called NQO1, converts NADH back to NAD+
  • ALA is a really powerful antioxidant, activates NRF2
  • ALA vs ALA-R
  • Sophora Japonica Extract Rutin, senolytic
  • NAMP
  • Aging is an inflicted cascade disorder
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