You Should Measure the Length of Your Critically-Short Telomeres – EP19: Stephen Matlin (Life Length)

In this nineteenth episode, Stephen Matlin introduces telomere biology. He details how testing services typically use Q-PCR which provides an average telomere length and why that doesn’t really mean anything.

Read the transcript

Instead the percentage of critically-short, measured using Q-FISH, does. Finally he chats about supplements – telomerase inducers – for growth.

Topics we discussed in this episode

• Introduction to telomere biology
• Hayflick limit, senescent cells, apoptosis
• Telomeres and the hallmarks of aging
• Quantitative PCR derived average telomere length vs shortest telomeres
• Coefficient of variation of lab samples
• Role of supplements in supporting our telomeres and overall biological function
• Declining nutrition in even vegetables
• Telomerase inducers TA-65 and TAM-818
• Telomerase enzyme
• Henrietta Lacks cells, cancer and the Hayflick limit
• Telomerase supplements and cancer
• Telomerase inducer Telomere Benefits™
• Providing biological age scores using telomere measurements
• Telomere length and correlation with healthspan
• Improving upon biomarker Prostate Specific Antigen with Prostate Telomere Associate Variance

Show links

• LifeLength.com (Company Website)
• T.A. Sciences TA-65 (UK/Europe)
• T.A. Sciences TA-65 (Amazon.com)
• Hayflick, His Limit, and Cellular Ageing (Paper)
• The Hayflick Limit (Embryo Project Encyclopedia)
• The End-Replication Problem (Paper)
• Leucocyte Telomere Length And Risk Of Cardiovascular Disease: Systematic Review And Meta-analysis (Paper)
• Association Between Leucocyte Telomere Length And Cardiovascular Disease In A Large General Population In The United States (Paper)
• The Hallmarks of Aging (Paper)
• Coefficient of Variation (Wikipedia Entry)
• A Natural Product Telomerase Activator Lengthens Telomeres in Humans: A Randomized, Double Blind, and Placebo Controlled Study (Paper)
• The Telomerase Activator Ta-65 Elongates Short Telomeres And Increases Health Span Of Adult/old Mice Without Increasing Cancer Incidence (Paper)
• Discovery Of Potent Telomerase Activators: Unfolding New Therapeutic And Anti-aging Perspectives (Paper)
• The Nobel Prize in Physiology or Medicine 2009 (Website)
• Defy Time (Website)
• Telomere Benefits™ (Product Link)
• Mathematical Connection Between Short Telomere Induced Senescence Calculation And Mortality Rate Data (Paper)
• Comparison Of Telomere Length Measurement Methods (Paper)
• Beyond Average: Potential For Measurement Of Short Telomeres (Paper)